Advanced glycation end products and diabetic complications: A General overview

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Advanced glycation end products and diabetic complications: a general overview.

Diabetes mellitus, especially type 2 diabetes is increasing at an alarming rate reaching epidemic proportions. Although hyperglycemia has been considered as playing an important role in the pathogenesis of diabetic complications, the mechanisms involved remain uncertain. There are several theories as to how chronic hyperglycemia can lead to micro or macrovascular disease in diabetes, including ...

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Advanced Glycation End Products and Diabetic Complications

During long standing hyperglycaemic state in diabetes mellitus, glucose forms covalent adducts with the plasma proteins through a non-enzymatic process known as glycation. Protein glycation and formation of advanced glycation end products (AGEs) play an important role in the pathogenesis of diabetic complications like retinopathy, nephropathy, neuropathy, cardiomyopathy along with some other di...

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Advanced glycation end products (AGEs) and diabetic vascular complications.

Diabetic vascular complication is a leading cause of acquired blindness, end-stage renal failure, a variety of neuropathies and accelerated atherosclerosis, which could account for disabilities and high mortality rates in patients with diabetes. Chronic hyperglycemia is essentially involved in the development and progression of diabetic micro- and macroangiopathy. Among various metabolic derang...

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Advanced glycation end products and diabetic nephropathy.

Chronic hyperglycemia and oxidative stress in diabetes results in the formation and accumulation advanced glycation end products (AGEs). AGEs have a wide range of chemical, cellular, and tissue effects that contribute to the development of microvascular complications. In particular, AGEs appear to have a key role in the diabetic nephropathy. Their importance as downstream mediators of tissue in...

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Advanced glycation end products in diabetic corneas.

PURPOSE Corneal complications are often associated with diabetes mellitus and can be vision threatening. Corneas in diabetic patients are exposed to increased glucose concentration despite cornea's avascular property, and this condition may contribute to the accumulation of advanced glycation end products (AGEs). The focus of this study was to examine the role of AGEs in the pathogenesis of dia...

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ژورنال

عنوان ژورنال: HORMONES

سال: 2005

ISSN: 1109-3099

DOI: 10.14310/horm.2002.11140